Ethyl 4-oxo-1-piperidinecarboxylate → HCID 67569461, compound

HRID 1418386Notes

Reaction equation

HRID 1418386 reaction equation
[ClH:1].Cl.[CH3:3][O:4][C:5]1[CH:13]=[CH:12][CH:11]=[C:10]([NH2:14])[C:6]=1[C:7]([NH2:9])=[NH:8].O=[C:16]1[CH2:21][CH2:20][N:19]([C:22]([O:24][CH2:25][CH3:26])=[O:23])[CH2:18][CH2:17]1>>[ClH:1].[NH2:8][C:7]1[C:6]2[C:10](=[CH:11][CH:12]=[CH:13][C:5]=2[O:4][CH3:3])[NH:14][C:16]2([CH2:21][CH2:20][N:19]([C:22]([O:24][CH2:25][CH3:26])=[O:23])[CH2:18][CH2:17]2)[N:9]=1

Participants

3

Reactant 2

HCID 34767Ethyl 4-oxo-1-piperidinecarboxylateHCID 67568446HCID 67568446, compound

Product 1

HCID 67569461HCID 67569461, compound

Procedure

This was prepared by the method of Example 173 using 2-methoxy-6-aminobenzamidine dihydrochloride (Example E) and ethyl 4-oxopiperidine-1-carboxylate to give the title compound as a yellow solid, MS (+CI) 319 ([M+H]+), 1H NMR (d6 -DMSO) 9.97 (1H, s), 8.69 (1H, s), 8.64 (1H, s), 7.70 (1H, s), 7.40 (1H, dd), 6.48 (1H, d), 6.42 (1H, d), 4.05 (2H, q), 3.88 (3H, s), 3.6-3.72 (2H, m), 3.4-3.55 (2H, m), 1.85-2.0 (2H, m), 163-1.80 (2H, m), 1.19 (3H, t).

Sources & evidence

ORD record
ord-ebdd7b90bf2f42ed98ba781082b0118f
Source dataset
uspto-grants-1999_03
Patent number
US05883102

Reaction notes

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