Ethyl 4-oxo-1-piperidinecarboxylate → HCID 67568671, compound

HRID 1418387Notes

Reaction equation

HRID 1418387 reaction equation
[ClH:1].Cl.[NH2:3][C:4]1[C:12]([F:13])=[CH:11][CH:10]=[C:9]([F:14])[C:5]=1[C:6]([NH2:8])=[NH:7].O=[C:16]1[CH2:21][CH2:20][N:19]([C:22]([O:24][CH2:25][CH3:26])=[O:23])[CH2:18][CH2:17]1>>[ClH:1].[NH2:7][C:6]1[C:5]2[C:4](=[C:12]([F:13])[CH:11]=[CH:10][C:9]=2[F:14])[NH:3][C:16]2([CH2:21][CH2:20][N:19]([C:22]([O:24][CH2:25][CH3:26])=[O:23])[CH2:18][CH2:17]2)[N:8]=1

Participants

3

Reactant 2

HCID 34767Ethyl 4-oxo-1-piperidinecarboxylateHCID 67568295HCID 67568295, compound

Product 1

HCID 67568671HCID 67568671, compound

Procedure

This was prepared by the method of Example 173 using 2-amino-3,6-difluorobenzamidine dihydrochloride (Example G) and ethyl 4-oxopiperidine-1-carboxylate to give the title compound, m.p. 228°-229° C.

Sources & evidence

ORD record
ord-f29314aeef1b49928c477203fcad61ef
Source dataset
uspto-grants-1999_03
Patent number
US05883102

Reaction notes

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