HCID 21192811, compound → HCID 21192802, compound

HRID 1418396Notes

Reaction equation

HRID 1418396 reaction equation
[NH2:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][C:10]=2[F:12])[NH:5][C:4]2([CH2:15][N:14](C(OCC3C=CC=CC=3)=O)[CH2:13]2)[N:3]=1>C(O)C.[Pd]>[F:12][C:10]1[CH:9]=[CH:8][CH:7]=[C:6]2[C:11]=1[C:2]([NH2:1])=[N:3][C:4]1([CH2:13][NH:14][CH2:15]1)[NH:5]2

Participants

4

Reactant 1

HCID 21192811HCID 21192811, compound

Product 1

HCID 21192802HCID 21192802, compoundYield 99%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

Phenylmethyl 4'-Amino-5'-fluorospiro[azetidine-3 ,2'(1'H)-quinazoline]-1 -carboxylate (Example 249, 1 g, 2.94 mmol) in ethanol (50 ml) containing 10% palladium on carbon catalyst (0.1 g) was stirred under hydrogen at 3 atmospheres pressure for 48 h. The catalyst was removed by filtration and the filtrate concentrated to leave the crude title compound as a gum (0.6 g), MS (+CI) 207 ([M+H]+).

Workup

  1. customThe catalyst was removed by filtration
  2. concentrationthe filtrate concentrated

Sources & evidence

ORD record
ord-027998cdb8584961a84922eb4ae00c17
Source dataset
uspto-grants-1999_03
Patent number
US05883102

Reaction notes

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