Dichloromethane → HCID 178526817, compound

HRID 1418441Notes

Reaction equation

HRID 1418441 reaction equation
[NH2:1][C:2]1[N:6]=[C:5]([C:7]2[CH:12]=[CH:11][C:10]([Cl:13])=[CH:9][CH:8]=2)[NH:4][N:3]=1.Br[C:15]1[S:16][C:17]([N+:20]([O-:22])=[O:21])=[CH:18][N:19]=1.O1CCCC1.ClCCl>CO>[Cl:13][C:10]1[CH:11]=[CH:12][C:7]([C:5]2[N:6]=[C:2]([NH:1][C:15]3[S:16][C:17]([N+:20]([O-:22])=[O:21])=[CH:18][N:19]=3)[NH:3][N:4]=2)=[CH:8][CH:9]=1

Participants

6

Reactant 4

HCID 6344DichloromethaneHCID 8028TetrahydrofuranHCID 182112-Bromo-5-nitrothiazoleHCID 6914123-(4-chlorophenyl)-1H-1,2,4-triazol-5-amine

Product 1

HCID 178526817HCID 178526817, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The title compound was prepared in a similar manner described in Example 1 by heating 3-amino-5-(4-chlorophenyl)-1,2,4-triazole with 2-bromo-5-nitrothiazole in refluxing tetrahydrofuran followed by silica gel column chromatograph by a solvent mixture of dichloromethane and methanol to yield 3-(4-chlorophenyl)-5-[(5-nitrothiazol-2-yl)amino]-1,2,4-triazole.

Workup

  1. customThe title compound was prepared in a similar manner

Sources & evidence

ORD record
ord-672ed460086e4d0fb5d2d6e232304e0d
Source dataset
uspto-grants-1999_03
Patent number
US05883110

Reaction notes

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