CJ-13454 → 1-[5-Fluoro-3-[4-(2-methylimidazol-1-yl)benzyloxy]phenyl]cyclopentane-1-carboxamide

HRID 1418449Notes

Reaction equation

HRID 1418449 reaction equation
FC1C=C(C2(C(OCC)=O)CCCC2)C=C(OCC2C=CC(N3C=CN=C3C)=CC=2)C=1.[F:32][C:33]1[CH:34]=[C:35]([O:48][CH2:49][C:50]2[CH:55]=[CH:54][C:53]([N:56]3[CH:60]=[CH:59][N:58]=[C:57]3[CH3:61])=[CH:52][CH:51]=2)[CH:36]=[C:37]([C:39]2([C:45]([NH2:47])=[O:46])[CH2:44][CH2:43]O[CH2:41][CH2:40]2)[CH:38]=1>>[F:32][C:33]1[CH:34]=[C:35]([O:48][CH2:49][C:50]2[CH:51]=[CH:52][C:53]([N:56]3[CH:60]=[CH:59][N:58]=[C:57]3[CH3:61])=[CH:54][CH:55]=2)[CH:36]=[C:37]([C:39]2([C:45]([NH2:47])=[O:46])[CH2:44][CH2:43][CH2:41][CH2:40]2)[CH:38]=1

Participants

3

Reactant 2

HCID 9931329CJ-13454HCID 18786351Ethyl 1-[3-fluoro-5-[4-(2-methylimidazol-1-yl)benzyloxy]phenyl]cyclopentane-1-carboxylate

Product 1

HCID 98007231-[5-Fluoro-3-[4-(2-methylimidazol-1-yl)benzyloxy]phenyl]cyclopentane-1-carboxamide

Procedure

The desired compound was prepared from ethyl 1-[3-fluoro-5-[4-(2-methylimidazol-1-yl)benzyloxy]phenyl]cyclopentane-1-carboxylate according to the preparation of 4-[5-fluoro-3-[4-(2-methylimidazol-1-yl)benzyloxy]phenyl]-3,4,5,6- tetrahydro-2H-pyran-4-carboxamide (Example 5).

Sources & evidence

ORD record
ord-1717b8aa0924448b8b1544e17dcb2522
Source dataset
uspto-grants-1999_03
Patent number
US05883106

Reaction notes

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