HCID 11380253, compound → HCID 11166621, compound

HRID 1418487Notes

Reaction equation

HRID 1418487 reaction equation
[F:1][C:2]1[C:7]([OH:8])=[CH:6][C:5]([F:9])=[CH:4][C:3]=1[C:10]1([C:16]([O:18][CH3:19])=[O:17])[CH2:15][CH2:14][O:13][CH2:12][CH2:11]1.Cl.[CH3:21][C:22]1[N:23]([C:27]2[CH:34]=[CH:33][C:30]([CH2:31]Cl)=[CH:29][CH:28]=2)[CH:24]=[CH:25][N:26]=1>>[F:1][C:2]1[C:7]([O:8][CH2:31][C:30]2[CH:29]=[CH:28][C:27]([N:23]3[CH:24]=[CH:25][N:26]=[C:22]3[CH3:21])=[CH:34][CH:33]=2)=[CH:6][C:5]([F:9])=[CH:4][C:3]=1[C:10]1([C:16]([O:18][CH3:19])=[O:17])[CH2:15][CH2:14][O:13][CH2:12][CH2:11]1

Participants

3

Reactant 2

HCID 11380253HCID 11380253, compoundHCID 187863424-(2-Methylimidazol-1-yl)benzyl chloride hydrochloride

Product 1

HCID 11166621HCID 11166621, compoundYield 49%

Procedure

Methyl 4-(2,5-difluoro-3-hydroxyphenyl)-3,4,5,6-tetrahydropyran-4-carboxylate was reacted with 4-(2-methylimidazol-1-yl)benzyl chloride hydrochloride according to the procedure described in Example 2H to give the titled compound in 49% yield as a yellow oil.

Sources & evidence

ORD record
ord-9e92fcac297d4e818b5fd74f93d3b54e
Source dataset
uspto-grants-1999_03
Patent number
US05883106

Reaction notes

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