Lactic Acid → HCID 86753902, compound
Reaction equation
[C:1]([OH:6])(=[O:5])[CH:2]([CH3:4])[OH:3].[C:7]1(=[O:12])[O:11][CH2:10][CH2:9][CH2:8]1.[Si]([O-])([O-])([O-])[O-].[Al+3].[Si]([O-])([O-])([O-])[O-].[Si]([O-])([O-])([O-])[O-].[Al+3].[Al+3].[Al+3]>>[C:1]([OH:6])(=[O:5])[CH:2]([CH3:4])[OH:3].[C:7]1(=[O:12])[O:11][CH2:10][CH2:9][CH2:8]1Participants
Conditions
- Temperature
- 150 °C
Procedure
The lactide obtained in Example 2 (10 g) and γ-butyrolactone (10 g) were put into a 100-ml reaction vessel equipped with a stirrer and a nitrogen-introducing tube. After substitution of nitrogen gas was carried out three times, the mixture was molten by stirring at 150° C. for 3 hours in a stream of nitrogen. To the resulting mixture was added 0.4 g of synthetic light aluminum silicate (Tomita Pharmaceutical Co., Ltd.), and the temperature was raised to 195°±5° C. The pressure was reduced gradually to 20 mmHg over 30 minutes, followed by stirring at 195°±5° C. for 3 hours. After the pressure was reduced gradually to 1 mmHg over 30 minutes, the mixture was stirred at 195°±5° C. for 7 hours to give lactic acid-butyrolactone copolymer in the molten state. The product was cooled to room temperature to give 14.15 g of light brown copolymer. The weight-average molecular weight of this copolymer was 88,000.
Workup
- customequipped with a stirrer
- additiona nitrogen-introducing tube
- temperaturethe temperature was raised to 195°±5° C
- waitThe pressure was reduced gradually to 20 mmHg over 30 minutes
- stirringby stirring at 195°±5° C. for 3 hours
- waitAfter the pressure was reduced gradually to 1 mmHg over 30 minutes
- stirringthe mixture was stirred at 195°±5° C. for 7 hours
Sources & evidence
- ORD record
- ord-0c9921013b8f40b89a752f3b73b37af6
- Source dataset
- uspto-grants-1999_03
- Patent number
- US05883222
Reaction notes
Loading…