HuagongsheHuagongshe Chemistry Print Report · For research reference only
Glyoxylic Acid → HCID 88289825, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Glyoxylic Acid | HCID 760 | — |
| Reactant | Bromocyclopentane | HCID 8728 | — |
| Reactant | O-(Tetrahydropyran-2-yl)hydroxylamine | HCID 5142091 | — |
| Reactant | HCID 88289252 | HCID 88289252 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | HCID 88289825 | HCID 88289825 | — |
Reaction Steps
The tetrahydropyranyl derivative (as used in Example 3) is prepared by treating the glyoxylic acid derivative described below with O-(tetrahydro-pyran-2-yl)-hydroxyl-amine in the presence of triethylamine in ethanol as depicted below: ##STR7## d) For the preparation of the cyclopentyl derivative the compound A is deprotonated and treated with cyclopentylbromide to form (Z)-2-(aminothiazol-4-yl)cyclopentyl-oxyimino acetic acid ethylester which is then hydrolysed to yield the free acid. The free acid is then reacted in analogy to example 1 to yield the activated acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05883247 |
| Source dataset | uspto-grants-1999_03 |
| ORD ID | ord-3c6c0ed19fb044fd9034743cfb61f3a0 |
| Source note | uspto-grants-1999_03 |