Hydrochloric Acid → HCID 53700197, compound

HRID 1418682Notes

Reaction equation

HRID 1418682 reaction equation
Cl.[OH:2][CH:3]([CH2:13][C@H:14]1[C@@H:18]([C:19]([F:22])([F:21])[F:20])[CH2:17][C:16](=N)[NH:15]1)CC1OC=C(C(O)=O)N=1.Cl.C[OH:26]>>[O:26]=[C:16]1[NH:15][CH:14]([CH2:13][CH:3]=[O:2])[CH:18]([C:19]([F:22])([F:21])[F:20])[CH2:17]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 178479091HCID 178479091, compound

Product 1

HCID 53700197HCID 53700197, compound

Procedure

Isomer B: (±) (cis) 2-[2-hydroxy-3-[5-imino-3-(trifluoromethyl)pyrrolidin-2-yl]propyl]oxazole-4-carboxylic acid, monohydrochloride ##STR229## 224 A) The product of Example 223 B in MeOH is treated with HCl (1N) to yield 5-oxo-3-(trifluoromethyl)pyrrolidine-2-acetaldehyde which is used directly in the next step.

Sources & evidence

ORD record
ord-d61b9cc24ad2467fac5b7c8e777ea8aa
Source dataset
uspto-grants-1999_03
Patent number
US05883251

Reaction notes

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