Trifluoroacetic acid → HCID 54138684, compound

Participants

Reaction Steps

The title compound was prepared according to the procedure in Example 3B except using (±)-12-cyano-8-methyl-7-[1-[[[[(1,1-dimethylethoxy)carbonyl]amino]acetyl]oxy]propyl]indolizino[1,2-b]quinolin-9(11H)-one. 1H NMR (CDCl3 /MeOH-d4) d 8.28 (d, J=8.5 Hz, 1H), 8.22 (d, J=8.4 Hz, 1H), 7.95 (m, 1H), 7.82 (m, 1H), 7.36 (s, 1H), 6.00 (apparent t, J=6.6 Hz, 1H), 5.41 (s, 2H), 3.92 (br s, 2H), 2.33 (s, 3H), 2.08-1.82 (m, 2H), 1.00 (t, J=7.2 Hz, 3H). Anal. Calcd for C22H20N4O3.3/2 CF3CO2H.5/2 H2O: C, 49.67; H, 4.42; N, 9.27. Found: C, 49.41; H, 4.23; N, 9.29.

Provenance & Evidence