Trifluoroacetic acid → HCID 54138684, compound

HRID 1418695Notes

Reaction equation

HRID 1418695 reaction equation
[C:1]([C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[N:6]=[C:5]2[C:13]3[N:18]([CH2:19][C:4]=12)[C:17](=[O:20])[C:16]([CH3:21])=[C:15]([CH:22]([O:25][C:26](=[O:36])[CH2:27][NH:28]C(OC(C)(C)C)=O)[CH2:23][CH3:24])[CH:14]=3)#[N:2].C(C(O)=O)(F)(F)F>O>[NH2:28][CH2:27][C:26]([O:25][CH:22]([C:15]1[CH:14]=[C:13]2[N:18]([CH2:19][C:4]3[C:5]2=[N:6][C:7]2[C:12]([C:3]=3[C:1]#[N:2])=[CH:11][CH:10]=[CH:9][CH:8]=2)[C:17](=[O:20])[C:16]=1[CH3:21])[CH2:23][CH3:24])=[O:36]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86753921HCID 86753921, compound

Product 1

HCID 54138684HCID 54138684, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The title compound was prepared according to the procedure in Example 3B except using (±)-12-cyano-8-methyl-7-[1-[[[[(1,1-dimethylethoxy)carbonyl]amino]acetyl]oxy]propyl]indolizino[1,2-b]quinolin-9(11H)-one. 1H NMR (CDCl3 /MeOH-d4) d 8.28 (d, J=8.5 Hz, 1H), 8.22 (d, J=8.4 Hz, 1H), 7.95 (m, 1H), 7.82 (m, 1H), 7.36 (s, 1H), 6.00 (apparent t, J=6.6 Hz, 1H), 5.41 (s, 2H), 3.92 (br s, 2H), 2.33 (s, 3H), 2.08-1.82 (m, 2H), 1.00 (t, J=7.2 Hz, 3H). Anal. Calcd for C22H20N4O3.3/2 CF3CO2H.5/2 H2O: C, 49.67; H, 4.42; N, 9.27. Found: C, 49.41; H, 4.23; N, 9.29.

Sources & evidence

ORD record
ord-fe1dcda9c84942568a483a78bc741b81
Source dataset
uspto-grants-1999_03
Patent number
US05883255

Reaction notes

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