Hydrochloric Acid → HCID 86753926, compound

HRID 1418699Notes

Reaction equation

HRID 1418699 reaction equation
I[CH2:2][C:3]([O:5][CH:6]([C:9]1[CH:25]=[C:24]2[N:12]([CH2:13][C:14]3[C:15]2=[N:16][C:17]2[C:22]([CH:23]=3)=[CH:21][CH:20]=[CH:19][CH:18]=2)[C:11](=[O:26])[C:10]=1[CH3:27])[CH2:7][CH3:8])=[O:4].[NH:28]1[CH:32]=[CH:31][N:30]=[CH:29]1.[ClH:33]>O>[ClH:33].[N:28]1([CH2:2][C:3]([O:5][CH:6]([C:9]2[CH:25]=[C:24]3[N:12]([CH2:13][C:14]4[C:15]3=[N:16][C:17]3[C:22]([CH:23]=4)=[CH:21][CH:20]=[CH:19][CH:18]=3)[C:11](=[O:26])[C:10]=2[CH3:27])[CH2:7][CH3:8])=[O:4])[CH:32]=[CH:31][N:30]=[CH:29]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 795ImidazoleHCID 86753922HCID 86753922, compound

Product 1

HCID 86753926HCID 86753926, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The title compound was prepared according to the procedure in Example 13 except using (±)-7-[1-[(iodoacetyl)oxy]propyl]-8-methylindolizino[1,2-b]quinolin-9(11H)-one and imidazole. 1H NMR (CDCl3 /MeOH-d4) d 9.17 (s, 1H), 8.60 (s, 1H), 8.34 (d, 1H), 8.04 (d, 1H), 7.95 (m, 1H), 7.75 (m, 1H), 7.61 (s, 1H), 7.51 (br s, 1H), 7.41 (br s, 1H), 5.95 (m, 1H), 5.65 (d, 1H), 5.42 (d, 1H), 5.33 (s, 2H), 2.36 (s, 3H), 2.1-1.9 (m, 2H), 1.07 (t, 3H). Anal. Calcd for C24H22N4O3.2 HCl.11/4 H2O: C, 53.68; H, 5.35; N, 10.43. Found: C, 53.52; H, 5.58; N, 10.29.

Sources & evidence

ORD record
ord-67fec67139b841c8b31bcff398d43598
Source dataset
uspto-grants-1999_03
Patent number
US05883255

Reaction notes

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