Pyridine → HCID 86753927, compound

HRID 1418700Notes

Reaction equation

HRID 1418700 reaction equation
[I:1][CH2:2][C:3]([O:5][CH:6]([C:9]1[CH:25]=[C:24]2[N:12]([CH2:13][C:14]3[C:15]2=[N:16][C:17]2[C:22]([CH:23]=3)=[CH:21][CH:20]=[CH:19][CH:18]=2)[C:11](=[O:26])[C:10]=1[CH3:27])[CH2:7][CH3:8])=[O:4].[N:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1>O>[I-:1].[CH3:27][C:10]1[C:11](=[O:26])[N:12]2[C:24](=[CH:25][C:9]=1[CH:6]([O:5][C:3](=[O:4])[CH2:2][N+:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)[CH2:7][CH3:8])[C:15]1=[N:16][C:17]3[C:22]([CH:23]=[C:14]1[CH2:13]2)=[CH:21][CH:20]=[CH:19][CH:18]=3

Participants

4

Reactant 2

HCID 1049PyridineHCID 86753922HCID 86753922, compound

Product 1

HCID 86753927HCID 86753927, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The title compound was prepared according to the procedure in Example 13 except using (±)-7-[1-[(iodoacetyl)oxy]propyl]-8-methylindolizino[1,2-b]quinolin-9(11H)-one and pyridine. 1H NMR (CDCl3 /MeOH-d4) d 9.09 (d, J=5.5 Hz, 2H), 8.65 (t, J=7.9 Hz, 1H), 8.51 (s, 1H), 8.17 (m, 3H), 7.99 (d, J=8.1 Hz, 1H). 7.89 (m, 1H), 7.70 (m, 1H), 7.50 (s, 1H), 6.05 (d, J=17.2 Hz, 1H), 6.02 (m, 1H).5.87 (d, J=17.2 Hz, 1H), 5.30 (s, 2H), 2.31 (s, 3H), 2.18-1.94 (m, 2H), 1.09 (t, J=7.4 Hz, 3H). Anal. Calcd for C26H24IN3O3.1/4 H2O: C, 55.97; H, 4.43; N, 7.53. Found: C, 55.72; H, 4.30; N, 7.26.

Sources & evidence

ORD record
ord-614be93eea4b42e8a73a0e7d78229491
Source dataset
uspto-grants-1999_03
Patent number
US05883255

Reaction notes

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