Potassium Cyanide → 3-Amino-2-[(1-methylethyl)thio]benzonitrile

HRID 1418732Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1418732
Cl[C:2]1[C:3]([S:9][CH:10]([CH3:12])[CH3:11])=[C:4]([CH:6]=[CH:7][CH:8]=1)[NH2:5].[C-:13]#[N:14].[K+]>O.O.[Ni](Cl)Cl.[Mn].CN(C)C=O>[NH2:5][C:4]1[C:3]([S:9][CH:10]([CH3:12])[CH3:11])=[C:2]([CH:8]=[CH:7][CH:6]=1)[C:13]#[N:14]

Komponenten

6

Edukt 2

HCID 9032Potassium CyanideHCID 27357473-Chloro-2-(isopropylthio)aniline

Produkt 1

HCID 536512113-Amino-2-[(1-methylethyl)thio]benzonitrileAusbeute 90 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 23930ManganeseKatalysatorHCID 10942802Nickel chloride dihydrateKatalysatorHCID 6228DimethylformamideLösungsmittel

Reaktionsbedingungen

Temperatur
50 °C

Versuchsvorschrift

6 liters of dimethylformamide are added to 50 g of nickel chloride dihydrate, 200 g of BPPFA (1,1'-bisdiphenylphosphine-1-(dimethylaminoethyl)ferrocene) and 49 g of manganese powder, and the mixture is stirred at 50° C. for 2 hours under an inert atmosphere. A brown suspension forms. 1,200 g of 3-chloro-2-isopropylthioaniline and 430 g of KCN are added to the suspension and the mixture is stirred for 16 hours at 50° C. After working up, white crystals of m.p. 82° C. are obtained in a yield of approximately 90%.

Aufarbeitung

  1. stirringthe mixture is stirred for 16 hours at 50° C
  2. customwhite crystals of m.p. 82° C. are obtained in a yield of approximately 90%

Quellen und Nachweise

ORD-Eintrag
ord-bed8d66093ae49b6aa687e225d62be2c
Quelldatensatz
uspto-grants-1999_03
Patentnummer
US05883283

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