Sodium Hydroxide → 4,6-Dimethoxy-2-(3-nitro-2-thienylthio)pyrimidine

HRID 1418820노트

반응식

HRID 1418820 반응식
[OH-].[Na+].[CH3:3][O:4][C:5]1[CH:10]=[C:9]([O:11][CH3:12])[N:8]=[C:7]([SH:13])[N:6]=1.Cl[C:15]1[S:16][CH:17]=[CH:18][C:19]=1[N+:20]([O-:22])=[O:21]>O.C(O)C>[CH3:12][O:11][C:9]1[CH:10]=[C:5]([O:4][CH3:3])[N:6]=[C:7]([S:13][C:15]2[S:16][CH:17]=[CH:18][C:19]=2[N+:20]([O-:22])=[O:21])[N:8]=1

참가 물질

6

반응물 3

HCID 14798Sodium HydroxideHCID 2201862-Chloro-3-nitrothiopheneHCID 178493561HCID 178493561, 화합물

생성물 1

HCID 538177994,6-Dimethoxy-2-(3-nitro-2-thienylthio)pyrimidine수율 83.1%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

실험 절차

Sodium hydroxide (1.2 g) was dissolved in water (50 ml), 4,6-dimethoxy-2-mercaptopyrimidine (5.3 g) was added, and the mixture was stirred at room temperature for 15 minutes. 2-Chloro-3-nitrothiophene (5.0 g) dissolved in ethanol (50 ml) was added with stirring, the mixture being stirred at room temperature for 6 hours. The resulting precipitate was filtered, washed with water and dried, to give 7.6 g of the desired product, mp 199°-201° C.

후처리

  1. additionwas added
  2. stirringwith stirring
  3. stirringthe mixture being stirred at room temperature for 6 hours
  4. filtrationThe resulting precipitate was filtered
  5. washwashed with water
  6. customdried

출처 및 근거

ORD 기록
ord-6c9985314deb4806b1790bc77d7bd1f6
출처 데이터셋
uspto-grants-1999_03
특허 번호
US05885935

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