Hydrochloric Acid → HCID 21842295, compound

HRID 1418909Notes

Reaction equation

HRID 1418909 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]3[CH:12]=[N:13][C:14]([C:15]4[O:16][C:17]([CH2:20][NH:21][CH2:22][CH2:23][CH3:24])=[CH:18][N:19]=4)=[C:10]3[CH2:9][N:8]([CH3:25])[C:7](=[O:26])[C:6]=2[CH:27]=1.[ClH:28]>C(O)C>[ClH:28].[F:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]3[CH:12]=[N:13][C:14]([C:15]4[O:16][C:17]([CH2:20][NH:21][CH2:22][CH2:23][CH3:24])=[CH:18][N:19]=4)=[C:10]3[CH2:9][N:8]([CH3:25])[C:7](=[O:26])[C:6]=2[CH:27]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21842244HCID 21842244, compound

Product 1

HCID 21842295HCID 21842295, compoundYield 74%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

1.14 g (0.0031 mol) of 8-fluoro-5-methyl-3-(5-propylaminomethyl-oxazol-2-yl)-5,6-dihydro-4H-imidazo[1,5-a][1,4]-benzodiazepin-6-one in 50 ml of ethanol were treated with 0.84 ml (0.0031 mol) of 3.7N ethanolic hydrochloric acid. After stirring at 0° for 1/2 hr. the white suspension was suction filtered. There was obtained 0.93 g (74%) of 8-fluoro-5-methyl-3-(5-propylaminomethyl-oxazol-2-yl)-5,6-dihydro-4H-imidazo-[1,5-a][1,4]benzodiazepin-6-one hydrochloride (1:1) as white crystals; m.p. 178°-181° (dec.).

Workup

  1. filtrationfiltered

Sources & evidence

ORD record
ord-959fe29fc60f46f8b9dca5946845b97d
Source dataset
uspto-grants-1999_03
Patent number
US05885986

Reaction notes

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