Hydrochloric Acid → HCID 21842293, compound

Participants

Reaction Steps

0.84 g (0.00212 mol) of 8-fluoro-5-methyl-3-(5-piperidin-1-ylmethyl-oxazol-2-yl)-5,6-dihydro-4H-imidazo[1,5-a][1,4]-benzodiazepin-6-one was dissolved in 30 ml of hot ethanol and treated at 50° with 0.60 ml (0.00227 mol) of 3.7N ethanolic hydrochloric acid. After stirring at 0° for 1 hr. the white suspension was suction filtered. There was obtained 0.80 g (87%) of 8-fluoro-5-methyl-3-(5-piperidin-1-ylmethyl-oxazol-2-yl)-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepin-6-one hydrochloride (1:1) as yellowish crystals; m.p. 276°-280° (dec.).

Provenance & Evidence