Hydrochloric Acid → HCID 21842293, compound

HRID 1418917Notes

Reaction equation

HRID 1418917 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]3[CH:12]=[N:13][C:14]([C:15]4[O:16][C:17]([CH2:20][N:21]5[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]5)=[CH:18][N:19]=4)=[C:10]3[CH2:9][N:8]([CH3:27])[C:7](=[O:28])[C:6]=2[CH:29]=1.[ClH:30]>C(O)C>[ClH:30].[F:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]3[CH:12]=[N:13][C:14]([C:15]4[O:16][C:17]([CH2:20][N:21]5[CH2:22][CH2:23][CH2:24][CH2:25][CH2:26]5)=[CH:18][N:19]=4)=[C:10]3[CH2:9][N:8]([CH3:27])[C:7](=[O:28])[C:6]=2[CH:29]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21842236HCID 21842236, compound

Product 1

HCID 21842293HCID 21842293, compoundYield 87.4%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

0.84 g (0.00212 mol) of 8-fluoro-5-methyl-3-(5-piperidin-1-ylmethyl-oxazol-2-yl)-5,6-dihydro-4H-imidazo[1,5-a][1,4]-benzodiazepin-6-one was dissolved in 30 ml of hot ethanol and treated at 50° with 0.60 ml (0.00227 mol) of 3.7N ethanolic hydrochloric acid. After stirring at 0° for 1 hr. the white suspension was suction filtered. There was obtained 0.80 g (87%) of 8-fluoro-5-methyl-3-(5-piperidin-1-ylmethyl-oxazol-2-yl)-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepin-6-one hydrochloride (1:1) as yellowish crystals; m.p. 276°-280° (dec.).

Workup

  1. filtrationfiltered

Sources & evidence

ORD record
ord-af87361fd6144375a4a31c8e64b5a752
Source dataset
uspto-grants-1999_03
Patent number
US05885986

Reaction notes

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