反应详情

0.56 g (0.0012 mol) (S)-8-chloro-1-(4-pyrrolidin-1-ylmethyl-thiazol-2-yl)-11,12,13,13a-tetrahydro-9H-imidazo-[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepin-9-one was suspended in 10 ml of water and treated with 12 ml of 0.1N (0.0012 mol) aqueous hydrochloric acid. After stirring at room temperature for 1 hr. the mixture was filtered and the filtrate was lyophilized. There was obtained 0.57 g (93%) of (S)-8-chloro-1-(4-pyrrolidin-1-ylmethyl-thiazol-2-yl)-11,12,13,13a-tetrahydro-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepin-9-one hydrochloride (1:1).

1. filtrationthe mixture was filtered