Hydrochloric Acid → HCID 86753965, compound

HRID 1418972Notes

Reaction equation

HRID 1418972 reaction equation
[Cl:1][C:2]1[C:7]2[C:8](=[O:30])[N:9]([CH3:29])[CH2:10][C:11]3[N:12]([CH:13]=[N:14][C:15]=3[C:16]3[O:17][CH:18]=[C:19](CN(C(C)C)C(C)C)[N:20]=3)[C:6]=2[CH:5]=[CH:4][CH:3]=1.Cl>C(O)C>[ClH:1].[Cl:1][C:2]1[C:7]2[C:8](=[O:30])[N:9]([CH3:29])[CH2:10][C:11]3[N:12]([CH:13]=[N:14][C:15]=3[C:16]3[O:17][C:18]([CH3:19])=[C:13]([N:12]([CH:6]([CH3:7])[CH3:5])[CH:11]([CH3:15])[CH3:10])[N:20]=3)[C:6]=2[CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21842256HCID 21842256, compound

Product 1

HCID 86753965HCID 86753965, compoundYield 187.2%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

0.10 g (0.00023 mol) of 7-chloro-3-(4-diisopropylaminomethyl-oxazol-2-yl)-5-methyl-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepin-6-one was dissolved in 10 ml of ethanol and treated with 0.063 ml (0.00023 mol) of 3.7N ethanolic hydrochloric acid. The solution was completely freed from the solvents and recrystallized from ethanol/diethyl ether. There was obtained 0.10 g (92%) of 7-chloro-3-(4-diisopropylamino-methyl-oxazol-2-yl)-5-methyl-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepin-6-one hydrochloride as white crystals; m.p. 228°-230°.

Workup

  1. customrecrystallized from ethanol/diethyl ether

Sources & evidence

ORD record
ord-36891c46625e4ba6b22acddc5695b819
Source dataset
uspto-grants-1999_03
Patent number
US05885986

Reaction notes

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