Sulfuric Acid → Isatin

HRID 1418978Notes

Reaction equation

HRID 1418978 reaction equation
[CH:1]1[CH:6]=[CH:5][C:4]([NH:7][C:8](/[CH:10]=N/O)=[O:9])=[CH:3][CH:2]=1.S(=O)(=O)(O)[OH:14]>>[NH:7]1[C:4]2[C:3](=[CH:2][CH:1]=[CH:6][CH:5]=2)[C:10](=[O:14])[C:8]1=[O:9]

Participants

3

Reactant 2

HCID 1118Sulfuric AcidHCID 6861488Acetamide, 2-(hydroxyimino)-N-phenyl-

Product 1

HCID 7054Isatin

Procedure

treating the isonitrosoacetanilide compound of step (1) with sulfuric acid, followed by ice and purification with ethanol to obtain an isatin compound of the formula ##STR42##

Workup

  1. customfollowed by ice and purification with ethanol

Sources & evidence

ORD record
ord-cface0f3cf9b474aa91f3096d3ef2aba
Source dataset
uspto-grants-1999_03
Patent number
US05885996

Reaction notes

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