反应详情

温度

50 °C

A mixture of 0.26 g of 5-[4-(1-benzylbenzimidazol-5-ylmethoxy)benzyl]-3-triphenylmethylthiazolidine-2,4-dione (prepared as described in Preparation 29), 3 ml of acetic acid and 1 ml of water was stirred for 3 hours at 50° C. in oil bath. At the end of this time, the reaction mixture was neutralized with sodium hydrogencarbonate and then extracted with ethyl acetate. The extract was washed with a saturated aqueous solution of sodium chloride and dried over anhydrous sodium sulfate. The solvent was then removed by evaporation under reduced pressure, and the resulting residue was recrystallized from a mixture of ethanol and methanol, to give 116 mg of the title compound, melting at 185°-187° C.

1. extractionextracted with ethyl acetate
2. washThe extract was washed with a saturated aqueous solution of sodium chloride
3. dry with materialdried over anhydrous sodium sulfate
4. customThe solvent was then removed by evaporation under reduced pressure
5. customthe resulting residue was recrystallized from a mixture of ethanol and methanol