反应详情

5-(4-Cyano-2-nitrophenyl)amino-3-(N-t-butoxycarbonyl-1,2,5,6-tetrahydropyrid-4-yl)-1H-indole was used. Reduction was by aqueous FeSO4 in ethanol, the cyclization reaction used ethoxymethylene malononitrile, and the cyclization reaction was heated for 56 hours. Chromatography using 5% acetone in methylene chloride afforded the title compound (10%) as a brown foam: Rf =0.5 in 5% acetone in methylene chloride; HRMS calculated for C26H25N5O2 439.2011, found 439.1999.

1. customthe cyclization reaction
2. customthe cyclization reaction
3. temperaturewas heated for 56 hours