HCID 70206768, compound → HCID 54270902, compound

HRID 1419150Notes

Reaction equation

HRID 1419150 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([C:14]2[C:22]3[C:17](=[CH:18][CH:19]=[C:20]([N:23]4[C:31]5[C:26](=[N:27][CH:28]=[CH:29][CH:30]=5)[NH:25][CH2:24]4)[CH:21]=3)[NH:16][CH:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C>C(Cl)Cl>[NH:8]1[CH2:13][CH2:12][CH:11]([C:14]2[C:22]3[C:17](=[CH:18][CH:19]=[C:20]([N:23]4[C:31]5[C:26](=[N:27][CH:28]=[CH:29][CH:30]=5)[NH:25][CH2:24]4)[CH:21]=3)[NH:16][CH:15]=2)[CH2:10][CH2:9]1

Participants

3

Reactant 1

HCID 70206768HCID 70206768, compound

Product 1

HCID 54270902HCID 54270902, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

1-[3-(N-t-Butoxycarbonylpiperid-4-yl)indol-5-yl]-3H-imidazo[4,5-b]pyridine was used, and methylene chloride was used as the solvent. Filtration afforded the title compound (100%) as a yellow solid: mp 260°-268° C. with effervescence; 13C NMR (CD3OD) δ 149.7, 145.6, 144.0, 138.5, 127.7, 126.0, 125.8, 125.5, 124.6, 123.9, 120.6, 119.7, 117.4, 113.7, 45.7, 32.6, 30.7; FAB LRMS (m/z, relative intensity) 318 (M+, 22), 277 (12), 261 (4), 235 (5), 185 (100).

Workup

  1. filtrationFiltration

Sources & evidence

ORD record
ord-39ab8720914747a18fa4a8c3e4420d9a
Source dataset
uspto-grants-1999_03
Patent number
US05886008

Reaction notes

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