反应详情

温度

40 °C

A solution containing 18.2 g of 2-hydroxy-6-cyano-1-naphthylacetic acid, 250 ml of methanol and 3 g of methanesulfonic acid was stirred at 40° C. to perform dissolution, followed by stirring at room temperature for 2 days. Then, 5 g of active carbon was added, followed by stirring for 30 minutes. Thereafter, the insoluble matter was filtered off and the solvent was distilled off under reduced pressure. To the residue was added 50 ml of 50% hydrous methanol, and then the precipitate was collected by filtration to obtain 13 g of the desired product.

1. dissolutiondissolution
2. stirringby stirring at room temperature for 2 days
3. additionThen, 5 g of active carbon was added
4. stirringby stirring for 30 minutes
5. filtrationThereafter, the insoluble matter was filtered off
6. distillationthe solvent was distilled off under reduced pressure
7. additionTo the residue was added 50 ml of 50% hydrous methanol
8. filtrationthe precipitate was collected by filtration