HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → 6-Amidino-1-carbamoylmethyl-2-naphthyl 4-morpholinomethylbenzoate.dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | Dicyclohexylcarbodiimide | HCID 10868 | — |
| Reactant | 4-(morpholinomethyl)benzoic acid | HCID 703507 | — |
| Reactant | 6-Amidino-1-carbamoylmethyl-2-naphthol.hydrochloride | HCID 136454270 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Water | HCID 962 | — |
| Product | 6-Amidino-1-carbamoylmethyl-2-naphthyl 4-morpholinomethylbenzoate.dihydrochloride | HCID 70131994 | 67.4% |
Reaction Steps
15 Milliliters of anhydrous pyridine was added to 612.2 mg of 4-morpholinomethylbenzoic acid, 703.9 mg of 6-amidino-1-carbamoylmethyl-2-naphthol.hydrochloride, 622.6 mg of DCC and 30.7 mg of DMAP, followed by stirring for 2 hours under cooling with ice and then 3 days under cooling with water. Thereafter, the same procedure as in Example 1 was carried out to obtain 440.7 mg of the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05885990 |
| Source dataset | uspto-grants-1999_03 |
| ORD ID | ord-73405350c5924db0a431027c685d57d4 |
| Source note | uspto-grants-1999_03 |