HRID1419222

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID1049

Pyridine

C5H5N

HCID10868

Dicyclohexylcarbodiimide

C13H22N2

HCID703507

4-(morpholinomethyl)benzoic acid

C12H15NO3

HCID136454270

未命名化合物

PRODUCTS

生成物

结构：Cl.Cl.N=C(N)c1ccc2c(CC(N)=O)c(OC(=O)c3ccc(CN4CCOCC4)cc3)ccc2c1

HCID70131994

未命名化合物

收率 67.4%

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID14284

N,N-Dimethylpyridin-4-amine

C7H10N2

溶剂HCID962

Water

H2O

PROCEDURE

实验过程

15 Milliliters of anhydrous pyridine was added to 612.2 mg of 4-morpholinomethylbenzoic acid, 703.9 mg of 6-amidino-1-carbamoylmethyl-2-naphthol.hydrochloride, 622.6 mg of DCC and 30.7 mg of DMAP, followed by stirring for 2 hours under cooling with ice and then 3 days under cooling with water. Thereafter, the same procedure as in Example 1 was carried out to obtain 440.7 mg of the desired product.

WORKUP

后处理

temperatureunder cooling with ice

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-73405350c5924db0a431027c685d57d4
来源数据集: uspto-grants-1999_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05885990
来源说明: uspto-grants-1999_03

反应 SMILES

N1C=CC=CC=1.[O:7]1[CH2:12][CH2:11][N:10]([CH2:13][C:14]2[CH:22]=[CH:21][C:17]([C:18]([OH:20])=[O:19])=[CH:16][CH:15]=2)[CH2:9][CH2:8]1.[ClH:23].[C:24]([C:27]1[CH:28]=[C:29]2[C:34](=[CH:35][CH:36]=1)[C:33]([CH2:37][C:38](=[O:40])[NH2:39])=[C:32](O)[CH:31]=[CH:30]2)(=[NH:26])[NH2:25].C1CCC(N=C=NC2CCCCC2)CC1>CN(C1C=CN=CC=1)C.O>[ClH:23].[ClH:23].[O:7]1[CH2:8][CH2:9][N:10]([CH2:13][C:14]2[CH:22]=[CH:21][C:17]([C:18]([O:20][C:32]3[CH:31]=[CH:30][C:29]4[C:34](=[CH:35][CH:36]=[C:27]([C:24](=[NH:25])[NH2:26])[CH:28]=4)[C:33]=3[CH2:37][C:38](=[O:40])[NH2:39])=[O:19])=[CH:16][CH:15]=2)[CH2:11][CH2:12]1