Hydrochloric Acid → 6-Amidino-1-(2-carboxyethyl)-2-naphthyl 4-aminoiminomethylaminobenzoate.dihydrochloride

Participants

Reaction Steps

300 Milliliters of 3.6% hydrochloric acid was added to 3.3 g of 6-amidino-1-(2-carbamoylethyl)-2-naphthyl 4-aminoiminomethylaminobenzoate.methanesulfonic acid hydrochloride, followed by stirring for 6 hours at 75°-80° C. Furthermore, the reaction mixture was stirried for 24 hours under cooling with ice. Then, the precipitate was collected by filtration and washed with a small amount of 15% hydrochloric acid and acetone to obtain 1.58 g of the desired product.

Provenance & Evidence