Hydrochloric Acid → 6-Amidino-1-(2-carboxyethyl)-2-naphthyl 4-aminoiminomethylaminobenzoate.dihydrochloride

HRID 1419252Notes

Reaction equation

HRID 1419252 reaction equation
[ClH:1].[NH2:2][N:3]=[CH:4][NH:5][C:6]1[CH:32]=[CH:31][C:9]([C:10]([O:12][C:13]2[CH:22]=[CH:21][C:20]3[C:15](=[CH:16][CH:17]=[C:18]([C:23](=[NH:25])[NH2:24])[CH:19]=3)[C:14]=2[CH2:26][CH2:27][C:28](=[O:30])N)=[O:11])=[CH:8][CH:7]=1.Cl.CS(O)(=O)=[O:36]>>[ClH:1].[ClH:1].[NH2:2][N:3]=[CH:4][NH:5][C:6]1[CH:32]=[CH:31][C:9]([C:10]([O:12][C:13]2[CH:22]=[CH:21][C:20]3[C:15](=[CH:16][CH:17]=[C:18]([C:23](=[NH:25])[NH2:24])[CH:19]=3)[C:14]=2[CH2:26][CH2:27][C:28]([OH:30])=[O:36])=[O:11])=[CH:8][CH:7]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 20255444Methanesulfonic acid hydrochlorideHCID 178511909HCID 178511909, compound

Product 1

HCID 1784787646-Amidino-1-(2-carboxyethyl)-2-naphthyl 4-aminoiminomethylaminobenzoate.dihydrochloride

Procedure

300 Milliliters of 3.6% hydrochloric acid was added to 3.3 g of 6-amidino-1-(2-carbamoylethyl)-2-naphthyl 4-aminoiminomethylaminobenzoate.methanesulfonic acid hydrochloride, followed by stirring for 6 hours at 75°-80° C. Furthermore, the reaction mixture was stirried for 24 hours under cooling with ice. Then, the precipitate was collected by filtration and washed with a small amount of 15% hydrochloric acid and acetone to obtain 1.58 g of the desired product.

Workup

  1. waitFurthermore, the reaction mixture was stirried for 24 hours
  2. temperatureunder cooling with ice
  3. filtrationThen, the precipitate was collected by filtration
  4. washwashed with a small amount of 15% hydrochloric acid and acetone

Sources & evidence

ORD record
ord-b3d46c65872e415e827e48ed2aac4c6c
Source dataset
uspto-grants-1999_03
Patent number
US05885990

Reaction notes

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