反应详情

温度

0 °C

A solution of 2-chloro-3-methylbenzoyl chloride (18.05 mmol), [prepared as described above] in dry CH2Cl2 (60 ml) was cooled to 0° C. and AICl3 (2.41 g, 1 eq.) was added. After ten minutes, anisole (1.96 ml, 1 eq.) was added. The resulting orange colored reaction mixture was allowed to warm to room temperature, stirred for 3 h and then poured on ice. The product was extracted into ether, washed with brine, and dried over MgSO4 . The solvent was evaporated in vacuo to give 3-(4-methoxybenzoyl)-2-chlorotoluene (4.55 g, 97% yield) as a solid, mp 64.7°-65.8° C.

1. additionAICl3 (2.41 g, 1 eq.) was added
2. waitAfter ten minutes
3. temperatureto warm to room temperature
4. additionpoured on ice
5. extractionThe product was extracted into ether
6. washwashed with brine
7. dry with materialdried over MgSO4
8. customThe solvent was evaporated in vacuo