反应详情

An aqueous solution of lithium hydroxide (2 g /10 ml of water) was added to a solution of methyl 2-(2-fluorophenyl)-2-(6-chloropyridazin-3-yl)acetate (4.25 g, 14.84 mmol) [prepared as described above] in methanol (30 ml). After 1.5 h, acetic acid (10 ml) was added and the stirring was continued overnight. The product was extracted into ether, and the extract was washed with water, aqueous NaHCO3, and brine, and dried over MgSO4. The solvent was removed in vacuo and the crude was chromatographed on a silica gel column (10% ethyl acetate in hexanes) to give 6-(2-fluorobenzyl)-3-chloropyridazine (2.56 g) as an oil.

1. waitthe stirring was continued overnight
2. extractionThe product was extracted into ether
3. washthe extract was washed with water, aqueous NaHCO3, and brine
4. dry with materialdried over MgSO4
5. customThe solvent was removed in vacuo
6. customthe crude was chromatographed on a silica gel column (10% ethyl acetate in hexanes)