Methanol → Propanoic acid, 2-(4-hydroxyphenoxy)-, methyl ester

HRID 1419549Notes

Reaction equation

HRID 1419549 reaction equation
[OH:1][C:2]1[CH:13]=[CH:12][C:5]([O:6][CH:7]([CH3:11])[C:8]([OH:10])=[O:9])=[CH:4][CH:3]=1.[CH3:14]O>Cl.O>[OH:1][C:2]1[CH:3]=[CH:4][C:5]([O:6][CH:7]([CH3:11])[C:8]([O:10][CH3:14])=[O:9])=[CH:12][CH:13]=1

Participants

5

Reactant 2

HCID 887MethanolHCID 1011822-(4-Hydroxy-phenoxy)-propionic acid

Product 1

HCID 366926Propanoic acid, 2-(4-hydroxyphenoxy)-, methyl esterYield 99.9%

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidCatalystHCID 962WaterSolvent

Procedure

Into a mixture of 191 g (1 mol) of 2-(4-hydroxyphenoxy)propionic acid, moist (5% of H2O content), and 160 g (5 mol) of methanol there was blown in 0.73 g (0.02 mol) of hydrogen chloride and the mixture was caused to react and purified in a manner similar to that described in example 1. There were obtained 196 g (100%) [content: 99,7%] of methyl 2-(4-hydroxyphenoxy)propionate (chloride value: 34 ppm; organic chlorine: <10 ppm, other impurities: <0,1%, [hydroxyphenoxypropionic acid not detectable]).

Workup

  1. customto react
  2. custompurified in a manner similar to

Sources & evidence

ORD record
ord-d991ebfb68ea46938ad804ccbf3de086
Source dataset
uspto-grants-1999_03
Patent number
US05886209

Reaction notes

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