反应详情

Add 1-3 moles of thionyl chloride or phosgene into (S)-2-(4-difluoromethoxyphenyl)-3-methylbutyric acid, and allow the mixture to react at 10° C. to reflux temperature of the solvent for 0.1-100 hours, preferably for 1-5 hours. After the reaction is completed, distill off the unreacted thionyl chloride or phosgene to give the (S)-2-(4-difluoromethoxyphenyl)-3-methylbutyryl chloride.

1. customto react at 10° C.
2. temperatureto reflux temperature of the solvent for 0.1-100 hours
3. distillationdistill off the unreacted thionyl chloride or phosgene