HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosgene → (S)-2-(4-difluoromethoxyphenyl)-3-methylbutyryl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosgene | HCID 6371 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | (S)-2-(4-difluoromethoxyphenyl)-3-methylbutyric acid | HCID 13118566 | — |
| Product | (S)-2-(4-difluoromethoxyphenyl)-3-methylbutyryl chloride | HCID 53862600 | — |
Reaction Steps
Add 1-3 moles of thionyl chloride or phosgene into (S)-2-(4-difluoromethoxyphenyl)-3-methylbutyric acid, and allow the mixture to react at 10° C. to reflux temperature of the solvent for 0.1-100 hours, preferably for 1-5 hours. After the reaction is completed, distill off the unreacted thionyl chloride or phosgene to give the (S)-2-(4-difluoromethoxyphenyl)-3-methylbutyryl chloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05886207 |
| Source dataset | uspto-grants-1999_03 |
| ORD ID | ord-7fc57907f8bc49e58a5fa23c35366488 |
| Source note | uspto-grants-1999_03 |