Trifluoroacetic acid methylene chloride → N-Methyl-N-[2-(piperidin-4-yl)phenyl]methanesulfonamide Trifluoroacetate

HRID 1419574Notes

Reaction equation

HRID 1419574 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[N:20]([CH3:25])[S:21]([CH3:24])(=[O:23])=[O:22])[CH2:10][CH2:9]1)=O)(C)(C)C.[F:26][C:27]([F:32])([F:31])[C:28]([OH:30])=[O:29].ClCCl>>[F:26][C:27]([F:32])([F:31])[C:28]([OH:30])=[O:29].[CH3:25][N:20]([C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=1[CH:11]1[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1)[S:21]([CH3:24])(=[O:23])=[O:22]

Participants

3

Reactant 2

HCID 21863450Trifluoroacetic acid methylene chlorideHCID 67553893N-[2-(1-t-Butoxycarbonylpiperidin-4-yl)phenyl]-N-methylmethanesulfonamide

Product 1

HCID 86753991N-Methyl-N-[2-(piperidin-4-yl)phenyl]methanesulfonamide Trifluoroacetate

Procedure

N-[2-(1-t-Butoxycarbonylpiperidin-4-yl)phenyl]-N-methylmethanesulfonamide (662 mg) was dissolved in trifluoroacetic acid-dichloromethane (10%, 50 mL) and stirred at room temperature 2 h. The solvent was evaporated under reduced pressure to give the title compound as a colourless gum (670 mg), m/e (ES+) 269 (MH+).

Workup

  1. customThe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-c75b51c4a6dd40fd82419d66578e5a77
Source dataset
uspto-grants-1999_03
Patent number
US05885999

Reaction notes

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