Hydrochloric Acid → HCID 70192900, compound

HRID 1419578Notes

Reaction equation

HRID 1419578 reaction equation
[ClH:1].C(OC([N:9]1[CH2:14][CH2:13][CH:12]([CH2:15][N:16]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[S:17]([CH3:20])(=[O:19])=[O:18])[CH2:11][CH2:10]1)=O)(C)(C)C>CO>[ClH:1].[C:21]1([N:16]([CH2:15][CH:12]2[CH2:11][CH2:10][NH:9][CH2:14][CH2:13]2)[S:17]([CH3:20])(=[O:19])=[O:18])[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 70192656HCID 70192656, compound

Product 1

HCID 70192900HCID 70192900, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Methanolic hydrogen chloride (4M, 20 mL) was added to a stirred, cooled (0° C.) suspension N-[(1-t-butoxycarbonylpiperidin-4-yl)methyl]-N-phenylmethanesulfonamide (2.84 g, 7.7 mmol) in methanol (10 mL) and the mixture was stirred at room temperature for 1 h. The solvent was evaporated under reduced pressure to give the title compound as a tan foam (2.34 g, 100%), δH (250 MHz, d6 -DMSO) 8.90 (2H, br m), 7.45-7.33 (5H, m), 3.53 (2H, d, J 7.0 Hz), 3.19 (2H, m), 2.96 (3H, s), 2.73 (2H, m), 1.80 (2H, m), 1.54 (1H, m), and 1.36 (2H, m).

Workup

  1. customThe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-01becf531138483983922016ad0946e1
Source dataset
uspto-grants-1999_03
Patent number
US05885999

Reaction notes

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