Hydrochloric Acid → HCID 67555450, compound

HRID 1419588Notes

Reaction equation

HRID 1419588 reaction equation
[ClH:1].C(OC([N:9]1[CH2:14][CH2:13][N:12]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[CH2:21][NH:22][S:23]([CH3:26])(=[O:25])=[O:24])[CH2:11][CH2:10]1)=O)(C)(C)C>CO>[ClH:1].[N:12]1([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[CH2:21][NH:22][S:23]([CH3:26])(=[O:25])=[O:24])[CH2:13][CH2:14][NH:9][CH2:10][CH2:11]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 542677021,1-Dimethylethyl 4-[2-[[(methylsulfonyl)amino]methyl]phenyl]-1-piperazinecarboxylate

Product 1

HCID 67555450HCID 67555450, compoundYield 99%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Methanolic hydrogen chloride (4M, 2.5 mL) was added to a stirred, cooled (0° C.) suspension of N-[2-(4-t-butoxycarbonylpiperazin-1-yl)phenylmethyl]methanesulfonamide (330 mg, 0.89 mmol) in methanol (1 mL) and the mixture was stirred at room temperature for 4 h. The solvent was evaporated under reduced pressure to give the title compound as an off-white solid (269 mg, 99%), δH (360 MHz, d6 -DMSO) 9.15 (2H, br s), 7.44 (1H, d, J 7.6 Hz), 7.42 (1H, br t, J 5.6 Hz), 7.31 (1H, t, J 7.6 Hz), 7.16 (2H, m), 4.22 (2H, d, J 5.6 Hz), 3.23 (4H, m), 3.06 (4H, m), and 2.92 (3H, s). m/e (ES+) 270 (MH+).

Workup

  1. temperaturecooled
  2. customThe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-76601a9d2b994f18a6885fb4ff00f69a
Source dataset
uspto-grants-1999_03
Patent number
US05885999

Reaction notes

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