Hydrochloric Acid → HCID 67555045, compound

HRID 1419590Notes

Reaction equation

HRID 1419590 reaction equation
[ClH:1].C(OC([N:9]1[CH2:14][CH2:13][N:12]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[CH2:21][NH:22][C:23](=[O:25])[CH3:24])[CH2:11][CH2:10]1)=O)(C)(C)C>CO>[ClH:1].[N:12]1([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[CH2:21][NH:22][C:23](=[O:25])[CH3:24])[CH2:11][CH2:10][NH:9][CH2:14][CH2:13]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 69411069HCID 69411069, compound

Product 1

HCID 67555045HCID 67555045, compoundYield 99%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Methanolic hydrogen chloride (4M, 5 mL) was added to a stirred, cooled (0° C.) suspension of N-[2-(4-t-butoxycarbonylpiperazin-1-yl)phenylmethyl]acetamide (668 mg, 2 mmol) in methanol (2 mL) and the mixture was stirred at room temperature for 4 h. The solvent was evaporated under reduced pressure to give the title compound as a colorless foam (536 mg, 99%), δH (360 MHz, d6 -DMSO) 9.20 (2H, br s), 8.26 (1H, br t, J 5.8 Hz), 7.26 (2H, m), 7.12 (2H, m), 4.33 (2H, d, J 5.8 Hz), 3.22 (4H, m), 3.04 (4H, m), and 1.89 (3H, s). m/e (ES+) 234 (MH+).

Workup

  1. temperaturecooled
  2. customThe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-7a5a873833d14ae5a5b3a58a209f474c
Source dataset
uspto-grants-1999_03
Patent number
US05885999

Reaction notes

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