Hydrochloric Acid → HCID 67555301, compound

HRID 1419591Notes

Reaction equation

HRID 1419591 reaction equation
[ClH:1].[CH3:2][N:3]([CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[N:12]1[CH2:17][CH2:16][N:15](C(OC(C)(C)C)=O)[CH2:14][CH2:13]1)[CH3:4]>CO>[ClH:1].[ClH:1].[CH3:4][N:3]([CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[N:12]1[CH2:13][CH2:14][NH:15][CH2:16][CH2:17]1)[CH3:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21935152HCID 21935152, compound

Product 1

HCID 67555301HCID 67555301, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Methanolic hydrogen chloride (4M, 2.5 mL) was added to a stirred, cooled (0° C.) solution of N,N-dimethyl-2-(4-t-butoxycarbonylpiperazin-1-yl)phenylmethylamine (392 mg, 1.2 mmol) in methanol (1 mL) and the mixture was stirred at room temperature for 4 h. The solvent was evaporated under reduced pressure to give the title compound as a colorless solid (350 mg, 100%), δH (360 MHz, d6 -DMSO) 9.92 (1H, br s), 9.26 (2H, br s), 7.62 (1H, d, J 7.7 Hz), 7.49 (1H, t, J 7.7 Hz), 7.31 (2H, m), 4.30 (2H, d, J 5.5 Hz), 3.31 (4H, m), 3.04 (4H, m), 2.73 (3H, s), and 2.72 (3H, s). m/e (ES+) 220 (MH+).

Workup

  1. customThe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-f2034a1ed2594ef69f8236cddcfbe0b3
Source dataset
uspto-grants-1999_03
Patent number
US05885999

Reaction notes

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