Lithium Chloride → Lithium tri-s-butylborohydride
Reaction equation
[CH:1]([BH-:5]([CH:10]([CH2:12][CH3:13])[CH3:11])[CH:6]([CH2:8][CH3:9])[CH3:7])([CH2:3][CH3:4])[CH3:2].[K+].[Li+:15].[Cl-]>C1COCC1>[CH:6]([BH-:5]([CH:10]([CH2:12][CH3:13])[CH3:11])[CH:1]([CH2:3][CH3:4])[CH3:2])([CH2:8][CH3:9])[CH3:7].[Li+:15]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 65 °C
Procedure
456.85 g of potassium tri-sec-butylborohydride (1.4 molar in THF) were added to a mixture of 29.7 g LiCl in 50 ml THF at 65° C. The reaction mixture was stirred for 2-4 hours at 65° C., cooled to room temperature and then filtered. The filter cake was then washed twice with 79.1 g THF. The filtrates were combined yielding lithium tri-sec-butyl borohydride in tetrahydrofuran as a clear, pale yellow liquid (99+% pure by atomic absorption).
Workup
- temperaturecooled to room temperature
- filtrationfiltered
- washThe filter cake was then washed twice with 79.1 g THF
Sources & evidence
- ORD record
- ord-8f3677c0af0041849a8a395dd62076fe
- Source dataset
- uspto-grants-1999_03
- Patent number
- US05886229
Reaction notes
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