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HRID1419661

反应详情

EQUATION

反应方程式

HRID 1419661 的结构方程式

REACTANTS

反应物

1
结构：COC(=O)[C@H]1[C@@H](c2ccc(I)cc2)C[C@@H]2CC[C@H]1N2C
HCID108220

Methyl (1R,2S,3S,5S)-3-(4-iodophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate

C16H20INO2

PRODUCTS

生成物

1
结构：CN1[C@H]2CC[C@@H]1[C@@H](C(=O)O)[C@@H](c1ccc(I)cc1)C2
HCID15639797

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：C1COCCO1.O
溶剂HCID21886435

1,4-Dioxane--water (1/1)

C4H10O3

PROCEDURE

实验过程

A round bottom flask filled with a solution of 100 mg of 2β-Carbomethoxy-3β-(4-Iodophenyl)tropane in 10 mL of 1:1 water/dioxane was heated to a gentle reflux for two days. The solvent was then removed and the white residue was triturated with hot ethyl acetate twice. The remaining solid was dried under in vacuo to yield 90 mg of CIT-acid 7, (93%) as a white solid.

WORKUP

后处理

  1. temperaturewas heated to
  2. temperaturea gentle reflux for two days
  3. customThe solvent was then removed
  4. customthe white residue was triturated with hot ethyl acetate twice
  5. customThe remaining solid was dried under in vacuo
  6. customto yield 90 mg of CIT-acid 7, (93%) as a white solid