反应详情

A solution of (S)-1-methyl-2-pyrrolidinemethanol (1.15 g) in THF (45 mL) was treated with potassium tert-butoxide (1.2 g). After 10 min, chloropyrazine was added and the reaction stirred for 1.5 h. The reaction was quenched with 5N HCl (4 mL) and the solvent evaporated. The residue was suspended in water and extracted with ether. The aqueous fraction was made basic and extracted with CHCl3. The extracts were dried, the solvent evaporated, and the residue purified by radial chromatography eluting with 20%-EtOH-2%-NH4OH--CHCl3 to give (S)-2-(1-methyl-2-pyrrolidinylmethoxy)pyrazine (1.1). The HCl salt crystallized from EtOAc as a white solid, m.p. 121°-122° C. (Compound 28)

1. customThe reaction was quenched with 5N HCl (4 mL)
2. customthe solvent evaporated
3. extractionextracted with ether
4. extractionextracted with CHCl3
5. customThe extracts were dried
6. customthe solvent evaporated
7. customthe residue purified by radial chromatography
8. washeluting with 20%-EtOH-2%-NH4OH--CHCl3