Sodium Nitrite → HCID 54509475, compound

HRID 1419760Notes

Reaction equation

HRID 1419760 reaction equation
[N:1]([O-])=O.[Na+].[CH3:5][N:6]1[C:10]([S:11](=[O:14])(=[O:13])[NH2:12])=[C:9]([C:15]([NH:17][NH2:18])=[O:16])[CH:8]=[N:7]1>O.Cl>[CH3:5][N:6]1[C:10]([S:11]([NH2:12])(=[O:13])=[O:14])=[C:9]([C:15]([N:17]=[N+:18]=[N-:1])=[O:16])[CH:8]=[N:7]1

Participants

5

Reactant 2

HCID 23668193Sodium NitriteHCID 54331888HCID 54331888, compound

Product 1

HCID 54509475HCID 54509475, compoundYield 50.2%

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 962WaterSolvent

Procedure

A solution of sodium nitrite (0.19 g) in 5 ml of water was added dropwise to a stirred solution of 1-methyl-5-sulfamoylpyrazole-4-carbohydrazide (0.55 g) in 8 ml of 1M hydrochloric acid at 0° C. The resulting mixture was stirred for 15 min and then filtered. The filter cake was washed with water and dried in vacuum to give 0.29 g (47%) of the title compound as a crystalline solid. The product was pure according to TLC (ethyl acetate) and was used immediately for the next step.

Workup

  1. filtrationfiltered
  2. washThe filter cake was washed with water
  3. customdried in vacuum

Sources & evidence

ORD record
ord-7d927425eec546d4938991b7de6cffa8
Source dataset
uspto-grants-1999_03
Patent number
US05889002

Reaction notes

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