反应详情

温度

55 °C

A mixture of 1-methyl-4-(ethoxycarbonylamino)pyrazole-5-sulfonamide (0.42 g), potassium carbonate (0.34 g) and isopropyl isothiocyanate (280 μl) in 10 ml of dry acetone was heated at 55° C. for 18 h and then evaporated to dryness. The residue was dissolved in 10 ml of water, and pH was adjusted to 2 by dropwise addition of 4M hydrochloric acid. The precipitate was filtered off, rinsed with a small amount of water and dried to give 0.38 g (64%) of the title compound; m.p. 141°-144° C.

1. customevaporated to dryness
2. dissolutionThe residue was dissolved in 10 ml of water
3. additionpH was adjusted to 2 by dropwise addition of 4M hydrochloric acid
4. filtrationThe precipitate was filtered off
5. washrinsed with a small amount of water
6. customdried