Potassium Carbonate → N-(4-Ethoxycarbonylamino-1-methyl-5-pyrazolesulfonyl)-N'-isopropylthiourea

関与物質

反応条件

反応手順

A mixture of 1-methyl-4-(ethoxycarbonylamino)pyrazole-5-sulfonamide (0.42 g), potassium carbonate (0.34 g) and isopropyl isothiocyanate (280 μl) in 10 ml of dry acetone was heated at 55° C. for 18 h and then evaporated to dryness. The residue was dissolved in 10 ml of water, and pH was adjusted to 2 by dropwise addition of 4M hydrochloric acid. The precipitate was filtered off, rinsed with a small amount of water and dried to give 0.38 g (64%) of the title compound; m.p. 141°-144° C.

情報源と証拠