反应详情

温度

125 °C

A mixture of 0.31 g of 7-chloro-1-ethyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid, 0.33 g of (4-pyridyl)piperazine and 2 ml of pyridine was stirred at 125° C. for 1 hour. After cooling, the reaction mixture was added to ice water to cause crystallization. The resulting crystal was collected by filtration, washed with ethyl ether and then recrystallized from ethanol to yield 0.1 g of the title compound.

1. temperatureAfter cooling
2. customcrystallization
3. filtrationThe resulting crystal was collected by filtration
4. washwashed with ethyl ether
5. customrecrystallized from ethanol