HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1419766Generated: October 25, 2026
1-(4-Pyridyl)piperazine → 1-Ethyl-6-fluoro-7-[4-(4-pyridyl)piperazin-1-yl]-1,4-dihydro-4-oxoquinoline-3-carboxylic acid
https://huagongshe.com/reaction/1419766
Participants
| Role | Name | HCID | Charge |
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| Reactant | 1-(4-Pyridyl)piperazine | HCID 70517 | — |
| Reactant | 7-Chloro-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid | HCID 483169 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 1-Ethyl-6-fluoro-7-[4-(4-pyridyl)piperazin-1-yl]-1,4-dihydro-4-oxoquinoline-3-carboxylic acid | HCID 15411477 | 21.9% |
Reaction Steps
A mixture of 0.31 g of 7-chloro-1-ethyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid, 0.33 g of (4-pyridyl)piperazine and 2 ml of pyridine was stirred at 125° C. for 1 hour. After cooling, the reaction mixture was added to ice water to cause crystallization. The resulting crystal was collected by filtration, washed with ethyl ether and then recrystallized from ethanol to yield 0.1 g of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05889009 |
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| Source dataset | uspto-grants-1999_03 |
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| ORD ID | ord-9573628676ff4a1f9cf6e7c235ed3c36 |
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| Source note | uspto-grants-1999_03 |
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