Citric Acid → HCID 131721208, compound

HRID 1419778Notes

Reaction equation

HRID 1419778 reaction equation
[N:1]1[N:2]=[CH:3][N:4]([C:6]2[CH:7]=[C:8]3[C:12](=[CH:13][CH:14]=2)[NH:11][CH:10]=[C:9]3[CH2:15][CH2:16][CH2:17][N:18]2[CH2:23][CH2:22][N:21]([CH2:24][CH2:25][C:26]3[CH:31]=[CH:30][CH:29]=[C:28]([F:32])[CH:27]=3)[CH2:20][CH2:19]2)[CH:5]=1.[C:33]([OH:45])(=[O:44])[CH2:34][C:35]([CH2:40][C:41]([OH:43])=[O:42])([C:37]([OH:39])=[O:38])[OH:36]>CO>[C:33]([OH:45])(=[O:44])[CH2:34][C:35]([CH2:40][C:41]([OH:43])=[O:42])([C:37]([OH:39])=[O:38])[OH:36].[C:33]([OH:45])(=[O:44])[CH2:34][C:35]([CH2:40][C:41]([OH:43])=[O:42])([C:37]([OH:39])=[O:38])[OH:36].[N:1]1[N:2]=[CH:3][N:4]([C:6]2[CH:7]=[C:8]3[C:12](=[CH:13][CH:14]=2)[NH:11][CH:10]=[C:9]3[CH2:15][CH2:16][CH2:17][N:18]2[CH2:19][CH2:20][N:21]([CH2:24][CH2:25][C:26]3[CH:31]=[CH:30][CH:29]=[C:28]([F:32])[CH:27]=3)[CH2:22][CH2:23]2)[CH:5]=1

Participants

4

Reactant 2

HCID 311Citric AcidHCID 6426760188400-51-3

Product 1

HCID 131721208HCID 131721208, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Conditions

Temperature
58 °C

Procedure

1-[3-(5-(1,2,4-Triazol-4-yl)-1H-indol-3-yl)propyl]-4-[2-(3-fluorophenyl)ethyl]piperazine was dissolved in methanol heated to 58° C. under a nitrogen atmosphere. Citric acid, in methanol at 58° C., was added, and the solution allowed to cool to ambient temperature, then left to stand for 16 hours. The mixture was filtered and the solid dried in vacuo at 50° C. to give the title compound, mp 176° C. (dec.).

Workup

  1. temperatureto cool to ambient temperature
  2. waitleft
  3. filtrationThe mixture was filtered
  4. customthe solid dried in vacuo at 50° C.

Sources & evidence

ORD record
ord-7856f11891b8488e9b5c9c883d4fcac5
Source dataset
uspto-grants-1999_03
Patent number
US05889008

Reaction notes

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