HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(2-Hydroxy-1,1,1-trifluoro-2-propyl)phenol benzyl ether → 4-(1,1,1-Trifluoro-2-hydroxypropan-2-yl)phenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(2-Hydroxy-1,1,1-trifluoro-2-propyl)phenol benzyl ether | HCID 57017446 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 4-(1,1,1-Trifluoro-2-hydroxypropan-2-yl)phenol | HCID 54439946 | — |
Reaction Steps
31.3 g (0.106 mol) of 4-(2-hydroxy-1,1,1-trifluoro-2-propyl)phenol benzyl ether were hydrogenated in 380 ml of glacial acetic acid in the presence of 6.3 g of palladium (5% on charcoal) at 50° C. After filtration to remove the catalyst and concentration, 18.9 g (87% of theory) remained of a colorless product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05889012 |
| Source dataset | uspto-grants-1999_03 |
| ORD ID | ord-9909e7d2c8354965856a6d8e6f5d6913 |
| Source note | uspto-grants-1999_03 |