Ammonia → HCID 178429768, compound

HRID 1419807Notes

Reaction equation

HRID 1419807 reaction equation
[CH3:1][C:2]1([CH:5]2[CH2:10][CH2:9][C:8](=O)[CH2:7][CH2:6]2)[CH2:4][CH2:3]1.[NH3:12].[H][H]>CO.[Rh]>[CH3:1][C:2]1([C@@H:5]2[CH2:10][CH2:9][C@H:8]([NH2:12])[CH2:7][CH2:6]2)[CH2:4][CH2:3]1

Participants

6

Reactant 3

HCID 222AmmoniaHCID 541016014-(1-Methylcyclopropyl)cyclohexanoneHCID 178418361HCID 178418361, compound

Product 1

HCID 178429768HCID 178429768, compound

Reagents, catalysts & solvents 2

HCID 23948RhodiumCatalystHCID 887MethanolSolvent

Procedure

11.0 g (72.3 mmol) of 4-(1 -methylcyclopropyl)cyclohexanone were stirred for 24 hours with 7.0 g (410 mmol) of NH3 dissolved in 120 ml of methanol, in the presence of 3.0 g of Rh/C (5%) at a hydrogen pressure of 20 bar and at a reaction temperature of 50° C. The reaction solution was filtered and the filtrate was concentrated. 9.8 g (88% of theory) were obtained of a colorless oil which was reacted without further purification.

Workup

  1. filtrationThe reaction solution was filtered
  2. concentrationthe filtrate was concentrated
  3. custom9.8 g (88% of theory) were obtained of a colorless oil which
  4. customwas reacted without further purification

Sources & evidence

ORD record
ord-da10a6610eab424999cb8645fa79ee63
Source dataset
uspto-grants-1999_03
Patent number
US05889012

Reaction notes

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